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    Synergistic interactions in haemopoiesis: biological implications and clinical use.

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    Authors
    Dexter, T Michael
    Affiliation
    Christie Hospital, Withington, Manchester, UK.
    Issue Date
    1993
    
    Metadata
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    Abstract
    Growth factors promote the survival and proliferation of haemopoietic stem and progenitor cells, and in their absence the haemopoietic cells undergo apoptosis and die. The results of studies reported here indicate that multipotent stem cells have receptors for most, if not all, of the growth factors, but that even saturated binding of the receptors for a single growth factor is not sufficient to transduce an effective stimulus for the proliferation of these cells (possibly due to very low receptor numbers). However, when the growth factors are combined synergistic effects can be seen. Studies in which stem cell factor was used in combination with other growth factors showed that stem cell factor allowed the survival of stem cells, while a second growth factor (granulocyte-macrophage colony-stimulating factor) stimulated the stem cells to develop normally. Stem cell factor was also shown to alter the dose-response relationships of developing haemopoietic cells for other growth factors.
    Citation
    Synergistic interactions in haemopoiesis: biological implications and clinical use. 1993, 29A Suppl 3:S6-9 Eur. J. Cancer
    Journal
    European Journal of Cancer
    URI
    http://hdl.handle.net/10541/101865
    DOI
    10.1016/0959-8049(93)90624-O
    PubMed ID
    8398366
    Type
    Article
    Language
    en
    ISSN
    0959-8049
    ae974a485f413a2113503eed53cd6c53
    10.1016/0959-8049(93)90624-O
    Scopus Count
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    All Paterson Institute for Cancer Research

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