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    The dose-fractionation sensitivity of the kidney; assessment of viable tubule cross-sections at 19 months after X irradiation.

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    Authors
    Jen, Yee-Min
    Hendry, Jolyon H
    Affiliation
    Department of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Manchester, UK.
    Issue Date
    1993-03
    
    Metadata
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    Abstract
    The formation of viable tubule cross-sections was assessed in histological sections of murine kidneys at 19 months after fractionated bilateral X-ray doses with 12 h intervals between fractions. The data were analysed using the linear-quadratic model which provides values of alpha and beta characterizing the slope of the dose-response curve, and the ratio of alpha and beta indicative of the sparing effect of dose fractionation. The tubule data were characterized by alpha = 0.057 +/- 0.009 Gy-1, beta = 0.011 +/- 0.001 Gy-2, alpha/beta = 5.0 +/- 0.9 Gy. Also, the number of cells (per focus region of the nephron) calculated as being capable of producing a viable focus was 2.5 +/- 0.5, which was confirmed using a separate two-dose approach (2.1 +/- 0.3). Together with other data, of the order of 1000 regenerative cells per nephron (10(4) total cells) can be deduced. The values of the fractionation sensitivity parameters are similar to values measured previously for cells taken from irradiated kidneys up to a year after irradiation and forming colonies in primary culture, and also similar to values assessed using various functional measures of kidney injury.
    Citation
    The dose-fractionation sensitivity of the kidney; assessment of viable tubule cross-sections at 19 months after X irradiation. 1993, 66 (783):241-4 Br J Radiol
    Journal
    British Journal of Radiology
    URI
    http://hdl.handle.net/10541/100405
    DOI
    10.1259/0007-1285-66-783-241
    PubMed ID
    8472117
    Type
    Article
    Language
    en
    ISSN
    0007-1285
    ae974a485f413a2113503eed53cd6c53
    10.1259/0007-1285-66-783-241
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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