• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    The expression of matrix metalloproteinases and their inhibitors by pig synovial cells and their regulation by combinations of cytokines and growth factors.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Legendre, P
    Richards, C D
    Rafferty, Joseph A
    Dew, G W
    Reynolds, J J
    Affiliation
    Cell and Molecular Biology Department, Strangeways Research Laboratory, Cambridge, U.K.
    Issue Date
    1993-11
    
    Metadata
    Show full item record
    Abstract
    1. Pig synovial fibroblasts in culture were studied to determine if they were an easily reproducible model system for studying the actions of cytokines and growth factors on human synovial cells. The biochemical analyses were conducted by activity assays, enzymography and Northern blot. 2. Human recombinant interleukin-1 alpha, basic fibroblast growth factor and transforming growth factor-beta 1 were studied in combinations because of their known involvement in controlling tissue remodelling. 3. The response of pig fibroblasts to these agents, in terms of the expression of matrix metalloproteinases (collagenase, gelatinase and stromelysin) and their inhibitors (TIMPs), show that they behave similarly enough to human cells for use when supplies of human primary cells are unavailable.
    Citation
    The expression of matrix metalloproteinases and their inhibitors by pig synovial cells and their regulation by combinations of cytokines and growth factors. 1993, 106 (3):691-704 Comp. Biochem. Physiol., B
    Journal
    Comparative Biochemistry and Physiology. B, Comparative Biochemistry
    URI
    http://hdl.handle.net/10541/100400
    DOI
    10.1016/0305-0491(93)90151-T
    PubMed ID
    8281764
    Type
    Article
    Language
    en
    ISSN
    0305-0491
    ae974a485f413a2113503eed53cd6c53
    10.1016/0305-0491(93)90151-T
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • Matrix metalloproteinases and tissue inhibitors of metalloproteinases in human gliomas.
    • Authors: Nakano A, Tani E, Miyazaki K, Yamamoto Y, Furuyama J
    • Issue date: 1995 Aug
    • Effects of immortalization upon the induction of matrix metalloproteinases in rabbit synovial fibroblasts.
    • Authors: Lin CW, Robbins PD, Georgescu HI, Evans CH
    • Issue date: 1996 Feb 25
    • The differential responses of human skin and synovial fibroblasts to stanozolol in vitro: production of prostaglandin E2 and matrix metalloproteinases.
    • Authors: Ellis AJ, Wright JK, Cawston TE, Hazleman BL
    • Issue date: 1992 Mar
    • Interleukin-1 and transforming growth factor-alpha: synergistic stimulation of metalloproteinases, PGE2, and proliferation in human fibroblasts.
    • Authors: Unemori EN, Ehsani N, Wang M, Lee S, McGuire J, Amento EP
    • Issue date: 1994 Feb
    • Regulation of matrix metalloproteinase expression in human vein and microvascular endothelial cells. Effects of tumour necrosis factor alpha, interleukin 1 and phorbol ester.
    • Authors: Hanemaaijer R, Koolwijk P, le Clercq L, de Vree WJ, van Hinsbergh VW
    • Issue date: 1993 Dec 15
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.