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    Dose-fractionation sensitivity of mouse kidney clonogens measured using different interfraction intervals and postirradiation assay times.

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    Authors
    Jen, Yee-Min
    Hendry, Jolyon H
    Affiliation
    Cancer Research Campaign Department of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Christie Hospital (NHS), Trust, Manchester, UK.
    Issue Date
    1993-02
    
    Metadata
    Show full item record
    Abstract
    The fractionation sensitivity of kidney clonogenic epithelial cells (X-irradiation in vivo, assay in vitro) was quantified using the linear-quadratic model. The cells were assayed either immediately after the fractionation schedule or after a time delay in order to compare the relative amounts of dose sparing due to fractionation (conventionally sublethal damage repair) and to post-irradiation delay intervals before assay (conventionally potentially-lethal damage repair). As the delay before assay was increased, there was a tendency for both alpha and beta to decrease, and as a consequence the alpha/beta ratio stayed virtually unchanged (3.3-4.4 Gy) regardless of delay time before assay. No change in survival was observed from 12 h to 6 weeks after neutron irradiation (62 MeVp-->Be), suggesting that the change observed after X-rays was due to repair rather than repopulation. As the interfraction intervals in an 8-fraction X-irradiation schedule were increased in steps from 6 h to 5 days, there was improved survival, consistent with the presence of long-term repair. These studies provide further evidence for the potential importance of long-term repair in late reacting tissues not only during but also after multifraction irradiation schedules.
    Citation
    Dose-fractionation sensitivity of mouse kidney clonogens measured using different interfraction intervals and postirradiation assay times. 1993, 26 (2):117-24 Radiother Oncol
    Journal
    Radiotherapy and Oncology
    URI
    http://hdl.handle.net/10541/100380
    DOI
    10.1016/0167-8140(93)90092-M
    PubMed ID
    8465011
    Type
    Article
    Language
    en
    ISSN
    0167-8140
    ae974a485f413a2113503eed53cd6c53
    10.1016/0167-8140(93)90092-M
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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