Evaluation of multiple biologic parameters in cervical carcinoma: high macrophage infiltration in HPV-associated tumors.
dc.contributor.author | Connor, M E | |
dc.contributor.author | Davidson, Susan E | |
dc.contributor.author | Stern, Peter L | |
dc.contributor.author | Arrand, John R | |
dc.contributor.author | West, Catharine M L | |
dc.date.accessioned | 2010-06-07T10:20:31Z | |
dc.date.available | 2010-06-07T10:20:31Z | |
dc.date.issued | 1993-03 | |
dc.identifier.citation | Evaluation of multiple biologic parameters in cervical carcinoma: high macrophage infiltration in HPV-associated tumors. 1993, 3 (2):103-109 Int. J. Gynecol. Cancer | en |
dc.identifier.issn | 1525-1438 | |
dc.identifier.pmid | 11578329 | |
dc.identifier.doi | 10.1046/j.1525-1438.1993.03020103.x | |
dc.identifier.uri | http://hdl.handle.net/10541/100377 | |
dc.description.abstract | A number of diverse biologic parameters have been assessed prior to treatment in a series of patients with cervical carcinoma. Factors analyzed were HPV DNA presence, MHC class I expression, expression of the oncofetal antigen 5T4, the proportions of macrophages, lymphocytes and granulocytes in cell suspensions prepared from tumors, in vitro colony-forming efficiency (CFE) and a measure of intrinsic radiosensitivity, surviving fraction at 2 Gy. Several associations were found. First, HPV DNA-negative tumors contained a small, but significant, decreased number of tumor infiltrating macrophages compared with HPV DNA-positive tumors. Secondly, patients with HPV-positive tumors were significantly younger than those where no HPV was detected. Thirdly, loss of one or more specific alleles in MHC class I positive tumors resulted in higher numbers of tumor lymphocytes and CFEs. Finally, strong expression of the 5T4 antigen was related to a reduction in the proportion of macrophages in tumor cell suspensions. In addition, for stage I and II patients expression of the MHC class I molecule was associated with improved survival compared with patients with tumors where loss of expression was seen. | |
dc.language | ENG | |
dc.language.iso | en | en |
dc.subject | Cervical Carcinoma | en |
dc.subject | Human Papillomavirus | en |
dc.subject | HPV | en |
dc.subject | Radiosensitivity | en |
dc.subject | Macrophage | en |
dc.title | Evaluation of multiple biologic parameters in cervical carcinoma: high macrophage infiltration in HPV-associated tumors. | en |
dc.type | Article | en |
dc.contributor.department | Cancer Research Campaign Departments of Immunology, Experimental Radiation Oncology and Molecular Biology, Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Wilmslow Road, Manchester, UK. | en |
dc.identifier.journal | International Journal of Gynecological Cancer | en |
html.description.abstract | A number of diverse biologic parameters have been assessed prior to treatment in a series of patients with cervical carcinoma. Factors analyzed were HPV DNA presence, MHC class I expression, expression of the oncofetal antigen 5T4, the proportions of macrophages, lymphocytes and granulocytes in cell suspensions prepared from tumors, in vitro colony-forming efficiency (CFE) and a measure of intrinsic radiosensitivity, surviving fraction at 2 Gy. Several associations were found. First, HPV DNA-negative tumors contained a small, but significant, decreased number of tumor infiltrating macrophages compared with HPV DNA-positive tumors. Secondly, patients with HPV-positive tumors were significantly younger than those where no HPV was detected. Thirdly, loss of one or more specific alleles in MHC class I positive tumors resulted in higher numbers of tumor lymphocytes and CFEs. Finally, strong expression of the 5T4 antigen was related to a reduction in the proportion of macrophages in tumor cell suspensions. In addition, for stage I and II patients expression of the MHC class I molecule was associated with improved survival compared with patients with tumors where loss of expression was seen. |