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    A polymerase chain reaction-based method for the detection of trisomy 12 in B chronic lymphocytic leukaemia.

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    Authors
    Baker, B W
    Heighway, Jim
    Browett, P J
    Norton, John D
    Affiliation
    CRC Department of Gene Regulation, Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Manchester, U.K.
    Issue Date
    1993-09
    
    Metadata
    Show full item record
    Abstract
    We report a polymerase chain reaction (PCR)-based method for detection of clonal trisomy 12 cell populations in B cell chronic lymphocytic leukaemia which is particularly applicable to retrospective analysis or archival material. The method utilizes three restriction enzyme site polymorphisms linked to the KRAS2 locus on chromosome 12 to monitor allele imbalance resulting from duplication of this chromosome. 21/24 unselected chronic lymphocytic leukaemia cases (88%) were informative for at least one polymorphism and of these, eight (33% of total cases) displayed allelic imbalance consistent with trisomy 12.
    Citation
    A polymerase chain reaction-based method for the detection of trisomy 12 in B chronic lymphocytic leukaemia. 1993, 85 (1):179-81 Br. J. Haematol.
    Journal
    British Journal of Haematology
    URI
    http://hdl.handle.net/10541/100353
    DOI
    10.1111/j.1365-2141.1993.tb08664.x
    PubMed ID
    8251388
    Type
    Article
    Language
    en
    ISSN
    0007-1048
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-2141.1993.tb08664.x
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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