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dc.contributor.authorWoods, Julie A
dc.contributor.authorHadfield, John A
dc.contributor.authorMcGown, Alan T
dc.contributor.authorFox, Brian W
dc.date.accessioned2010-06-03T15:10:33Z
dc.date.available2010-06-03T15:10:33Z
dc.date.issued1993-11
dc.identifier.citationBioactivity and molecular modelling of diphenylsulfides and diphenylselenides. 1993, 1 (5):333-40 Bioorg. Med. Chem.en
dc.identifier.issn0968-0896
dc.identifier.pmid8081863
dc.identifier.doi10.1016/S0968-0896(00)82139-2
dc.identifier.urihttp://hdl.handle.net/10541/100235
dc.description.abstractBis(2-bromo-4,5-dimethoxyphenyl)sulfide (5) and bis(2-bromo-4,5-dimethoxyphenyl) selenide (7) have been shown to block cells in the G2/M phase of the cell cycle, whereas the debromo (4,6) equivalents do not. The biobromoselenide (7) is cytotoxic to tumour cells in vitro and has been shown to increase the mitotic index of treated cells. These biological effects are consistent with disruption of the mitotic apparatus. This agent does not inhibit microtubule assembly in vitro, but does bind to tubulin. Molecular modelling of these structures indicates that their spatial and electronic structures may make an important contribution to the biological activity.
dc.language.isoenen
dc.subjectLeukaemia P388en
dc.subjectOvarian Canceren
dc.subjectCultured Tumour Cellsen
dc.subject.meshAnimals
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshLeukemia P388
dc.subject.meshMice
dc.subject.meshModels, Molecular
dc.subject.meshMolecular Structure
dc.subject.meshOvarian Neoplasms
dc.subject.meshSelenium Compounds
dc.subject.meshStructure-Activity Relationship
dc.subject.meshSulfides
dc.subject.meshThermodynamics
dc.subject.meshTubulin
dc.subject.meshTumor Cells, Cultured
dc.titleBioactivity and molecular modelling of diphenylsulfides and diphenylselenides.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Experimental Chemotherapy, Pateson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalBioorganic & Medicinal Chemistryen
html.description.abstractBis(2-bromo-4,5-dimethoxyphenyl)sulfide (5) and bis(2-bromo-4,5-dimethoxyphenyl) selenide (7) have been shown to block cells in the G2/M phase of the cell cycle, whereas the debromo (4,6) equivalents do not. The biobromoselenide (7) is cytotoxic to tumour cells in vitro and has been shown to increase the mitotic index of treated cells. These biological effects are consistent with disruption of the mitotic apparatus. This agent does not inhibit microtubule assembly in vitro, but does bind to tubulin. Molecular modelling of these structures indicates that their spatial and electronic structures may make an important contribution to the biological activity.


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