Bioactivity and molecular modelling of diphenylsulfides and diphenylselenides.
Affiliation
CRC Department of Experimental Chemotherapy, Pateson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.Issue Date
1993-11
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Bis(2-bromo-4,5-dimethoxyphenyl)sulfide (5) and bis(2-bromo-4,5-dimethoxyphenyl) selenide (7) have been shown to block cells in the G2/M phase of the cell cycle, whereas the debromo (4,6) equivalents do not. The biobromoselenide (7) is cytotoxic to tumour cells in vitro and has been shown to increase the mitotic index of treated cells. These biological effects are consistent with disruption of the mitotic apparatus. This agent does not inhibit microtubule assembly in vitro, but does bind to tubulin. Molecular modelling of these structures indicates that their spatial and electronic structures may make an important contribution to the biological activity.Citation
Bioactivity and molecular modelling of diphenylsulfides and diphenylselenides. 1993, 1 (5):333-40 Bioorg. Med. Chem.Journal
Bioorganic & Medicinal ChemistryDOI
10.1016/S0968-0896(00)82139-2PubMed ID
8081863Type
ArticleLanguage
enISSN
0968-0896ae974a485f413a2113503eed53cd6c53
10.1016/S0968-0896(00)82139-2
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