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    Bioactivity and molecular modelling of diphenylsulfides and diphenylselenides.

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    Authors
    Woods, Julie A
    Hadfield, John A
    McGown, Alan T
    Fox, Brian W
    Affiliation
    CRC Department of Experimental Chemotherapy, Pateson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.
    Issue Date
    1993-11
    
    Metadata
    Show full item record
    Abstract
    Bis(2-bromo-4,5-dimethoxyphenyl)sulfide (5) and bis(2-bromo-4,5-dimethoxyphenyl) selenide (7) have been shown to block cells in the G2/M phase of the cell cycle, whereas the debromo (4,6) equivalents do not. The biobromoselenide (7) is cytotoxic to tumour cells in vitro and has been shown to increase the mitotic index of treated cells. These biological effects are consistent with disruption of the mitotic apparatus. This agent does not inhibit microtubule assembly in vitro, but does bind to tubulin. Molecular modelling of these structures indicates that their spatial and electronic structures may make an important contribution to the biological activity.
    Citation
    Bioactivity and molecular modelling of diphenylsulfides and diphenylselenides. 1993, 1 (5):333-40 Bioorg. Med. Chem.
    Journal
    Bioorganic & Medicinal Chemistry
    URI
    http://hdl.handle.net/10541/100235
    DOI
    10.1016/S0968-0896(00)82139-2
    PubMed ID
    8081863
    Type
    Article
    Language
    en
    ISSN
    0968-0896
    ae974a485f413a2113503eed53cd6c53
    10.1016/S0968-0896(00)82139-2
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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