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dc.contributor.authorChomiczewski, K
dc.contributor.authorHendry, Jolyon H
dc.contributor.authorPotten, Christopher S
dc.date.accessioned2010-06-03T14:44:17Z
dc.date.available2010-06-03T14:44:17Z
dc.date.issued1993-01
dc.identifier.citationAccelerated repopulation of intestine post-irradiation following intraluminal injection of a mucosal cell suspension or its supernatant. 1993, 26 (1):64-8 Radiother Oncolen
dc.identifier.issn0167-8140
dc.identifier.pmid8438088
dc.identifier.doi10.1016/0167-8140(93)90027-6
dc.identifier.urihttp://hdl.handle.net/10541/100230
dc.description.abstractThe injection of (1-7) x 10(5) mucosal cells into the intestinal lumen at 4 h after 14 or 18 Gy increased the number of intestinal microcolonies (> or = 10 cell foci) and microclusters (4-9 cell foci) when assayed at day 3. The effects were less when (a) the interval between irradiation and injection was increased to 20 h, (b) the assay time was increased to 4 days or more, (c) a cell supernatant was injected instead. The data indicate that the injections stimulated earlier regeneration. The effect of the supernatant suggests that the stimulation is mediated through a humoral factor.
dc.language.isoenen
dc.subject.meshAnimals
dc.subject.meshCell Division
dc.subject.meshGamma Rays
dc.subject.meshInjections
dc.subject.meshIntestinal Mucosa
dc.subject.meshIntestine, Small
dc.subject.meshMale
dc.subject.meshMice
dc.subject.meshMice, Inbred Strains
dc.titleAccelerated repopulation of intestine post-irradiation following intraluminal injection of a mucosal cell suspension or its supernatant.en
dc.typeArticleen
dc.contributor.departmentCancer Research Campaign Department of Experimental Radiation Oncology, Christie Hospital (NHS) Trust, Manchester, UK.en
dc.identifier.journalRadiotherapy and Oncologyen
html.description.abstractThe injection of (1-7) x 10(5) mucosal cells into the intestinal lumen at 4 h after 14 or 18 Gy increased the number of intestinal microcolonies (> or = 10 cell foci) and microclusters (4-9 cell foci) when assayed at day 3. The effects were less when (a) the interval between irradiation and injection was increased to 20 h, (b) the assay time was increased to 4 days or more, (c) a cell supernatant was injected instead. The data indicate that the injections stimulated earlier regeneration. The effect of the supernatant suggests that the stimulation is mediated through a humoral factor.


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