Lack of association of HLA polymorphisms with human papillomavirus-related cervical cancer.
AuthorsGlew, Susan S
Duggan-Keen, Margaret F
Ghosh, Anna K
Dyer, P A
Stern, Peter L
AffiliationDepartment of Immunology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, England.
MetadataShow full item record
AbstractAn association of HLA-DQ3 with SCC of the cervix has been reported by researchers in Germany and Norway. This article documents a similar-sized study with patients and controls from northwest England. We report in detail on serologically determined HLA polymorphism in SCC patients with respect to HPV 16 infection, MHC class II expression within the tumor, serologic response to HPV, and other relevant clinical variables. We have also extended our studies to include DNA-based analysis using PCR and SSO probes for HLA-DQ. No significant association of any HLA-A, -B, -C, -DR, or -DQ antigen with SCC patients was found. While a possible explanation of the differences among studies could be a reflection of disease heterogeneity, the several tumor and clinical factors examined do not account for the observed differences from previous reports. Further studies are needed for a greater understanding of the interaction of HPV and HLA type in the development of cervical neoplasia.
CitationLack of association of HLA polymorphisms with human papillomavirus-related cervical cancer. 1993, 37 (3):157-64 Hum. Immunol.
- Cervical carcinoma: human papillomavirus infection and HLA-associated risk factors in the Spanish population.
- Authors: Montoya L, Saiz I, Rey G, Vela F, Clerici-Larradet N
- Issue date: 1998 Oct
- HLA class I expression and HPV-16 sequences in premalignant and malignant lesions of the cervix.
- Authors: Torres LM, Cabrera T, Concha A, Oliva MR, Ruiz-Cabello F, Garrido F
- Issue date: 1993 Feb
- HLA DR-DQ associations with cervical carcinoma show papillomavirus-type specificity.
- Authors: Apple RJ, Erlich HA, Klitz W, Manos MM, Becker TM, Wheeler CM
- Issue date: 1994 Feb
- Human leukocyte antigen class I/II alleles and development of human papillomavirus-related cervical neoplasia: results from a case-control study conducted in the United States.
- Authors: Hildesheim A, Schiffman M, Scott DR, Marti D, Kissner T, Sherman ME, Glass AG, Manos MM, Lorincz AT, Kurman RJ, Buckland J, Rush BB, Carrington M
- Issue date: 1998 Nov
- Tumor necrosis factor A and MHC class I chain related gene A (MIC-A) polymorphisms in Swedish patients with cervical cancer.
- Authors: Ghaderi M, Nikitina Zake L, Wallin K, Wiklund F, Hallmans G, Lenner P, Dillner J, Sanjeevi CB
- Issue date: 2001 Oct