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    Lack of association of HLA polymorphisms with human papillomavirus-related cervical cancer.

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    Authors
    Glew, Susan S
    Duggan-Keen, Margaret F
    Ghosh, Anna K
    Ivinson, A
    Sinnott, P
    Davidson, J
    Dyer, P A
    Stern, Peter L
    Affiliation
    Department of Immunology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, England.
    Issue Date
    1993-07
    
    Metadata
    Show full item record
    Abstract
    An association of HLA-DQ3 with SCC of the cervix has been reported by researchers in Germany and Norway. This article documents a similar-sized study with patients and controls from northwest England. We report in detail on serologically determined HLA polymorphism in SCC patients with respect to HPV 16 infection, MHC class II expression within the tumor, serologic response to HPV, and other relevant clinical variables. We have also extended our studies to include DNA-based analysis using PCR and SSO probes for HLA-DQ. No significant association of any HLA-A, -B, -C, -DR, or -DQ antigen with SCC patients was found. While a possible explanation of the differences among studies could be a reflection of disease heterogeneity, the several tumor and clinical factors examined do not account for the observed differences from previous reports. Further studies are needed for a greater understanding of the interaction of HPV and HLA type in the development of cervical neoplasia.
    Citation
    Lack of association of HLA polymorphisms with human papillomavirus-related cervical cancer. 1993, 37 (3):157-64 Hum. Immunol.
    Journal
    Human Immunology
    URI
    http://hdl.handle.net/10541/100228
    DOI
    10.1016/0198-8859(93)90181-Y
    PubMed ID
    8244779
    Type
    Article
    Language
    en
    ISSN
    0198-8859
    ae974a485f413a2113503eed53cd6c53
    10.1016/0198-8859(93)90181-Y
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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