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    A linkage study in seven breast cancer families.

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    Authors
    Teare, M Dawn
    Santibanez-Koref, Mauro F
    Wallace, S A
    White, Gavin R M
    Evans, D Gareth R
    Burnell, Liza D
    Harris, Martin
    Howell, Anthony
    Birch, Jillian M
    Affiliation
    Cancer Research Campaign Pediatric and Familial Cancer Research Group, Christie Hospital, Manchester, England.
    Issue Date
    1993-04
    
    Metadata
    Show full item record
    Abstract
    Seven breast cancer families are examined for evidence of linkage to a site in the region of 17q12-q21, by using five markers. The families constitute a subset of a larger series of familial breast cancer; the seven families were selected because constitutional DNA was available on informative members, either from clinical samples or extracted from paraffin blocks. Two-point lod scores are reported. The maximum lod score, 0.8824, is obtained with marker NM23 at theta = 0. This is clearly not significant in itself; however, when taken in context with evidence from existing reports, it provides support for linkage to this region.
    Citation
    A linkage study in seven breast cancer families. 1993, 52 (4):786-8 Am. J. Hum. Genet.
    Journal
    American Journal of Human Genetics
    URI
    http://hdl.handle.net/10541/100068
    PubMed ID
    8460644
    Type
    Article
    Language
    en
    ISSN
    0002-9297
    Collections
    All Christie Publications
    All Paterson Institute for Cancer Research

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