Influence of growth factors and substrates on differentiation of haemopoietic stem cells.
Affiliation
Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK.Issue Date
1993-12
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During the last few years there has been major progress in our understanding of the mechanisms underlying the regulation of haemopoietic stem cell proliferation and development. In the past 12 months, advances have been made in identifying how growth factor receptor expression is regulated in primitive haemopoietic cells, in determining the transcription factors that are associated with development, and in recognizing some of the specific molecular interactions that occur between the bone marrow stromal cells and the haemopoietic progenitor cells. These and previous studies clearly demonstrate that the environment can influence the survival, the proliferation and the differentiation of haemopoietic cells at every stage of development.Citation
Influence of growth factors and substrates on differentiation of haemopoietic stem cells. 1993, 5 (6):1044-9 Curr. Opin. Cell Biol.Journal
Current Opinion in Cell BiologyDOI
10.1016/0955-0674(93)90090-DPubMed ID
8129942Type
ArticleLanguage
enISSN
0955-0674ae974a485f413a2113503eed53cd6c53
10.1016/0955-0674(93)90090-D
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