RadiologyRadiologyhttp://hdl.handle.net/10541/567952024-03-29T05:02:30Z2024-03-29T05:02:30ZThe role of positron emission tomography in management of small cell lung cancer.Thomson, David JHulse, PaulLorigan, Paul CFaivre-Finn, Corinnehttp://hdl.handle.net/10541/2309152019-08-30T13:29:45Z2011-08-01T00:00:00ZThe role of positron emission tomography in management of small cell lung cancer.
Thomson, David J; Hulse, Paul; Lorigan, Paul C; Faivre-Finn, Corinne
Accurate radiological staging of small-cell lung cancer (SCLC) is of paramount importance in selection of individual patients with limited stage disease for potentially curative treatment while avoiding toxic treatment in those with distant metastatic disease. [(18)F] flurodeoxy-D-glucose (FDG) positron emission tomography (PET) is an attractive tool for this purpose but there is limited evidence to support its use in the routine staging of SCLC. Whether therapeutic decisions based on FDG-PET imaging should be made remains uncertain. There is only preliminary evidence for use of FDG-PET as a prognostic biomarker, in the assessment of response to treatment and delineation of disease in conformal radiation planning.
2011-08-01T00:00:00ZAssessment of circulating biomarkers for potential pharmacodynamic utility in patients with lymphoma.Greystoke, AlastairO'Connor, James P BLinton, Kim MTaylor, M BenCummings, JeffreyWard, Timothy HMaders, FranHughes, AnthonyRanson, Malcolm RIllidge, Timothy MRadford, John ADive, Carolinehttp://hdl.handle.net/10541/2009122019-08-30T13:37:02Z2011-02-15T00:00:00ZAssessment of circulating biomarkers for potential pharmacodynamic utility in patients with lymphoma.
Greystoke, Alastair; O'Connor, James P B; Linton, Kim M; Taylor, M Ben; Cummings, Jeffrey; Ward, Timothy H; Maders, Fran; Hughes, Anthony; Ranson, Malcolm R; Illidge, Timothy M; Radford, John A; Dive, Caroline
Treatment efficacy and toxicity are difficult to predict in lymphoma patients. In this study, the utility of circulating biomarkers in predicting and/or monitoring treatment efficacy/toxicity were investigated.
2011-02-15T00:00:00ZIs dual-phase abdominal CT necessary for the optimal detection of metastases from renal cell carcinoma?Jain, YatinLiew, STaylor, M BBonington, Suzanne Chttp://hdl.handle.net/10541/1924692019-08-30T13:23:15Z2011-11-01T00:00:00ZIs dual-phase abdominal CT necessary for the optimal detection of metastases from renal cell carcinoma?
Jain, Yatin; Liew, S; Taylor, M B; Bonington, Suzanne C
To determine whether dual-phase abdominal computed tomography (CT) detected more metastases than portal-phase CT alone in patients with renal cell carcinoma (RCC).
2011-11-01T00:00:00ZSerum vascular endothelial growth factor (VEGF) is elevated in GH deficient adults.Murray, Robert DRandeva, Harpal SLewandowski, Krzysztof CKomorowski, JanLawrance, Jeremy A LAdams, Judith EShalet, Stephen Mhttp://hdl.handle.net/10541/1358902019-08-30T13:31:56Z2011-04-01T00:00:00ZSerum vascular endothelial growth factor (VEGF) is elevated in GH deficient adults.
Murray, Robert D; Randeva, Harpal S; Lewandowski, Krzysztof C; Komorowski, Jan; Lawrance, Jeremy A L; Adams, Judith E; Shalet, Stephen M
GHD adults exhibit a number of adverse surrogate markers of vascular risk culminating in excess vascular morbidity and mortality. Vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) have been implicated in the pathogenesis of a number of vascular morbidities. Furthermore, serum levels decrease following GH replacement in GHD adults, though it remains unclear if levels are significantly elevated in untreated individuals.
2011-04-01T00:00:00Z