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DNA methylation and repressive H3K9 and H3K27 trimethylation in the promoter regions of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, and PD-L1 genes in human primary breast cancer.

Sasidharan, Nair V
; 
El Salhat, H
; 
Taha, R
; 
John, A
; 
Ali, B
; 
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Abstract
High expression of immune checkpoints in tumor microenvironment plays significant roles in inhibiting anti-tumor immunity, which is associated with poor prognosis and cancer progression. Major epigenetic modifications in both DNA and histone could be involved in upregulation of immune checkpoints in cancer.
Authors
Sasidharan, Nair V
El Salhat, H
Taha, R
John, A
Ali, B
Elkord, Eyad
Affiliation
Cancer Research Center, Qatar Biomedical Research Institute, College of Science and Engineering, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar.
Description
Date
2018
Publisher
Collections
All Paterson Institute for Cancer Research
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Article
Citation
DNA methylation and repressive H3K9 and H3K27 trimethylation in the promoter regions of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, and PD-L1 genes in human primary breast cancer. 2018, 10: 78 Clin Epigenetics
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http://hdl.handle.net/10541/621154
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