Stimulation of UV-induced DNA excision repair by chemotherapeutic drugs in cancer patients.
Roth, M Rogers, S Roberts, S S Boyle, John M Müller, H J Weber, W
Roth, M
Rogers, S
Roberts, S S
Boyle, John M
Müller, H J
Weber, W
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Abstract
We have used a monoclonal antibody specific for UV-induced 6-4 photoproducts in an ELISA assay to determine the kinetics of loss of antigenicity from the DNA of lymphocytes obtained from four groups of people; normal controls and cancer patients who had either received chemotherapy, hormone therapy or no treatment at all. This result was confirmed on a matched pairs analysis of 12 breast cancer patients sampled before and after chemotherapy. We conclude, that chemotherapeutic treatment with alkylating agents modulate the capacity of UV-induced DNA-repair in human lymphocytes in a yet unknown way.
Description
Date
1994
Publisher
Collections
Keywords
Cancer
Type
Article
Citation
Stimulation of UV-induced DNA excision repair by chemotherapeutic drugs in cancer patients., 14 (3A):809-15 Anticancer Res.