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The tyrosine kinase inhibitor crizotinib does not have clinically meaningful activity in heavily pre-treated patients with advanced alveolar rhabdomyosarcoma with FOXO rearrangement: European Organisation for Research and Treatment of Cancer phase 2 trial 90101 'CREATE'.
Schöffski, P ; Wozniak, A ; Leahy, Michael G ; Aamdal, S ; Rutkowski, P ; Bauer, S ; Richter, S ; Grünwald, V ; Debiec-Rychter, M ; Sciot, R ... show 5 more
Schöffski, P
Wozniak, A
Leahy, Michael G
Aamdal, S
Rutkowski, P
Bauer, S
Richter, S
Grünwald, V
Debiec-Rychter, M
Sciot, R
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Abstract
Alveolar rhabdomyosarcomas (ARMSs) can harbour MET and anaplastic lymphoma kinase (ALK) alterations. We prospectively assessed crizotinib in patients with advanced/metastatic ARMS.
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Date
2018-05
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Type
Article
Citation
The tyrosine kinase inhibitor crizotinib does not have clinically meaningful activity in heavily pre-treated patients with advanced alveolar rhabdomyosarcoma with FOXO rearrangement: European Organisation for Research and Treatment of Cancer phase 2 trial 90101 'CREATE'. 2018, 94: 156-167 Eur J Cancer