A recA-ada hybrid gene inducible by DNA damage.
Kleibl, K Margison, Geoffrey P Skorvaga, M Brozmanová, J Masek, F
Kleibl, K
Margison, Geoffrey P
Skorvaga, M
Brozmanová, J
Masek, F
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Abstract
A damage-inducible expression vector was constructed in which the original recA structural gene was replaced by the protein-coding region of the ada gene. The O6-alkylguanine-DNA alkyltransferase encoded by the ada gene can be measured by a rapid and highly sensitive assay. The introduction of this construct into an appropriate host cell provides an effective bacterial assay for genotoxins.
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Date
1992-05
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Article
Citation
A recA-ada hybrid gene inducible by DNA damage. 1992, 282 (1):39-42 Mutat. Res.