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An annotation infrastructure for the analysis and interpretation of Affymetrix exon array data.

Okoniewski, Michal J
; 
Yates, Tim
; 
Dibben, Sian
; 
Miller, Crispin J
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Abstract
Affymetrix exon arrays contain probesets intended to target every known and predicted exon in the entire genome, posing significant challenges for high-throughput genome-wide data analysis. X:MAP http://xmap.picr.man.ac.uk, an annotation database, and exonmap http://www.bioconductor.org/packages/2.0/bioc/html/exonmap.html, a BioConductor/R package, are designed to support fine-grained analysis of exon array data. The system supports the application of standard statistical techniques, prior to the use of genome scale annotation to provide gene-, transcript- and exon-level summaries and visualization tools.
Authors
Okoniewski, Michal J
Yates, Tim
Dibben, Sian
Miller, Crispin J
Affiliation
Bioinformatics Group, Cancer Research UK, Paterson Institute for Cancer Research, The University of Manchester, Christie Hospital Site, Wilmslow Road, Manchester M20 4BX, UK. mokoniewski@picr.man.ac.uk
Description
Date
2007
Publisher
Collections
All Paterson Institute for Cancer Research
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Type
Article
Citation
An annotation infrastructure for the analysis and interpretation of Affymetrix exon array data. 2007, 8 (5):R79 Genome Biol.
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URI
http://hdl.handle.net/10541/70462
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