Correlation of drug resistance-associated parameters in ovarian tumor biopsies.
McGown, Alan T Murphy, D Swindell, Ric Crowther, Derek Fox, Brian W
McGown, Alan T
Murphy, D
Swindell, Ric
Crowther, Derek
Fox, Brian W
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Abstract
This work compares glutathione levels, glutathione S-transferase activities and isoenzyme expression, metallothionein levels and P-glycoprotein expression in normal ovaries, and in epithelial ovarian tumor biopsies from patients prior to chemotherapy or following relapse. These parameters have been implicated as determinants of response to cytotoxic chemotherapy. Large differences were found between normal ovary and ovarian tumors, but no significant differences were observed between tumors taken before or after cytotoxic chemotherapy. These data do not support a role for these biochemical parameters in the decreased response seen in patients with recurrent or progressive disease.
Description
Date
1994-07
Publisher
Keywords
Glutathione-S-Transferases
Metallothionein
Multidrug Resistance
Ovarian Cancer
Metallothionein
Multidrug Resistance
Ovarian Cancer
Type
Article
Citation
Correlation of drug resistance-associated parameters in ovarian tumor biopsies. 1994, 4 (4):241-249 Int. J. Gynecol. Cancer