Bryostatin 1 induces productive Epstein-Barr virus replication in latently infected cells: implications for use in immunocompromised patients.
Stewart, James P McGown, Alan T Prendiville, Joseph A Pettit, G R Fox, Brian W Arrand, John R
Stewart, James P
McGown, Alan T
Prendiville, Joseph A
Pettit, G R
Fox, Brian W
Arrand, John R
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Abstract
Bryostatin 1 is a novel anti-tumor agent currently undergoing clinical trial. We investigated the effect of this drug on B-lymphocyte cell lines that carry the Epstein-Barr virus and found that it induces these latently infected cells into the production of transforming virus particles over a wide range of concentrations. These results may have clinical implications, particularly with regard to the use of the drug in the immunocompromised patient.
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Date
1993
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Collections
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Article
Citation
Bryostatin 1 induces productive Epstein-Barr virus replication in latently infected cells: implications for use in immunocompromised patients. 1993, 33 (1):89-91 Cancer Chemother. Pharmacol.