The survival of curaxins in the cancer arena
Theocharous, G. Papaspyropoulos, A. Gorgoulis, Vassilis G
Theocharous, G.
Papaspyropoulos, A.
Gorgoulis, Vassilis G
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Abstract
With DNA damage being a primary anti-cancertarget, a need has arisen for the development of an approach that is a harmlessfor normal tissues but allows for cancer cell-specific cytotoxicity. Previous researchfrom K. Gurova's suggests that small compounds, namely curaxins that bind theDNA can cause chromatin instability and cell death in a cancer cell-specificmanner. In this brief perspective commentary, we investigate how the scientificcommunity has further developed this anti-cancer approach.
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Date
2023
Publisher
Collections
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Article
Citation
Theocharous G, Papaspyropoulos A, Gorgoulis V. The survival of curaxins in the cancer arena. BioEssays : news and reviews in molecular, cellular and developmental biology. 2023 Jul 11:e2300112. PubMed PMID: 37431695. Epub 2023/07/11. eng.