Balancing hormone therapy: mitigating adverse effects of androgen-deprivation therapy and exploring alternatives in prostate cancer management
Gudenkauf, L. M. Gray, Struan Gonzalez, B. D. Sachdeva, Ashwin Autio, K.
Gudenkauf, L. M.
Gray, Struan
Gonzalez, B. D.
Sachdeva, Ashwin
Autio, K.
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Abstract
Androgen-deprivation therapy (ADT) is well established as the standard of care in metastatic prostate cancer (PCa) management; however, ADT has significant adverse effects (AEs) that must be addressed. This review aims to highlight opportunities to mitigate AEs of ADT and explore alternatives in PCa management. Specifically, we discuss behavioral and pharmacologic strategies for mitigating ADT AEs as well as ADT-sparing approaches for hormone-sensitive and castration-resistant PCa. Equipped with effective mitigation strategies and possible alternatives, clinicians and researchers can optimize health-related quality of life for patients currently receiving ADT for PCa and consider treatments that spare patients from AEs of ADT.
Description
Date
2024
Publisher
Collections
Keywords
Type
Article
Citation
Gudenkauf LM, Gray S, Gonzalez BD, Sachdeva A, Autio K. Balancing Hormone Therapy: Mitigating Adverse Effects of Androgen-Deprivation Therapy and Exploring Alternatives in Prostate Cancer Management. American Society of Clinical Oncology educational book American Society of Clinical Oncology Annual Meeting. 2024 Jun;44(3):e433126. PubMed PMID: 38788186. Epub 2024/05/24. eng.