Alpha-v integrins as therapeutic targets in oncology.
Nemeth, Jeffrey A Nakada, Marian T Trikha, M Lang, Zhihui Gordon, Michael S Corringham, Robert E Prabhakar, Uma Davis, Hugh M Beckman, Robert A
Nemeth, Jeffrey A
Nakada, Marian T
Trikha, M
Lang, Zhihui
Gordon, Michael S
Corringham, Robert E
Prabhakar, Uma
Davis, Hugh M
Beckman, Robert A
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Abstract
Integrins are heterodimeric cell adhesion receptors that mediate intercellular communication through cell-extracellular matrix interactions and cell-cell interactions. Integrins have been demonstrated to play a direct role in cancer progression, specifically in tumor cell survival, tumor angiogenesis, and metastasis. Therefore, agents targeted against integrin function have potential as effective anticancer therapies. Numerous anti-integrin agents, including monoclonal antibodies and small-molecule inhibitors, are in clinical development for the treatment of solid and hematologic tumors. This review focuses on the role of alpha(v) integrins in cancer progression, the current status of integrin-targeted agents in development, and strategies for the clinical development of anti-integrin therapies.
Description
Date
2007-10
Publisher
Collections
Keywords
Cancer Metastasis
Cancer Etiology
Cancer Drug Therapy
Cancer Etiology
Cancer Drug Therapy
Type
Article
Citation
Alpha-v integrins as therapeutic targets in oncology. 2007, 25 (7):632-46 Cancer Invest.