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Correlation analysis confirms differences in antioxidant defence in the blood of types I and II schizophrenic male patients treated with anti-psychotic medication.
Miljević, Cedo Nikolić-Kokić, Aleksandra Saicić, Zorica S Milosavljević, Maja Blagojević, Dusko Tosevski, Dusica Lecić Jones, David R Spasić, Mihajlo B
Miljević, Cedo
Nikolić-Kokić, Aleksandra
Saicić, Zorica S
Milosavljević, Maja
Blagojević, Dusko
Tosevski, Dusica Lecić
Jones, David R
Spasić, Mihajlo B
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Abstract
The activities of antioxidant defence enzymes were determined in erythrocytes isolated from types I and II schizophrenic male patients and from healthy controls. Significant differences in superoxide dismutase (SOD) activity (type I: 3284+/-577; type II: 2959+/-697 compared with controls: 3778+/-577; analysis of variance (ANOVA) P<0.001), catalase (CAT) activity (type I: 17.8+/-1.8 compared to type II: 19.2+/-1.5 and both compared with controls: 19.2+/-1.5; ANOVA P<0.05), glutathione peroxidase (GSH-Px) activity (controls: 17.8+/-2.3; type I: 13.9+/-2.9 and type II: 11.6+/-1.9; ANOVA P<0.001) as well as in glutathione reductase (GR) activity (controls: 5,0+/-0.8; type I: 4.3+/-0.9 and type II: 4.5+/-0.8; ANOVA P<0.01) were apparent. Correlation analysis of antioxidant defence enzymes showed significant negative correlation between GSH-Px and CAT activities (P<0.01) in type I patients. In type II patients, GSH-Px activity was significantly positively correlated with GR (P<0.01). Canonical discriminant analysis separated type I and type II patients from controls (and among each other) with a high degree of certainty according to the overall group composition of antioxidant defence enzymes. Our results indicate differences in the composition of antioxidant defence between controls and anti-psychotic treated type I and type II patients with a possible negative feedback influence on the pathological process, which could provide a rationale for applying antioxidants during schizophrenic therapy.
Description
Date
2010-06-30
Publisher
Collections
Keywords
Schizophrenia
Erythrocytes
Oxidative Stress
Superoxide Dismutase
Catalase
Erythrocytes
Oxidative Stress
Superoxide Dismutase
Catalase
Type
Article
Citation
Correlation analysis confirms differences in antioxidant defence in the blood of types I and II schizophrenic male patients treated with anti-psychotic medication. 2010, 178 (1):68-72 Psychiatry Res