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Involvement of alkylating agents in schistosome-associated bladder cancer: the possible basic mechanisms of induction.
Badawi, Alaa F Mostafa, M H O'Connor, Peter J
Badawi, Alaa F
Mostafa, M H
O'Connor, Peter J
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Abstract
Carcinoma of the urinary bladder is a common malignancy in many tropical and subtropical countries. There is a well documented sequela of chronic urinary schistosomal infection and bladder cancer associated with schistosomiasis is a major cause of morbidity and mortality in the endemic areas. Experimental bladder cancer can be induced in schistosome-infected animals. Multiple factors have been suggested as causative agents in schistosome-associated bladder carcinogenesis and the N-nitroso compounds appear to be of particular importance. These agents have long been suspected to play a major role in the aetiology of a variety of human cancers. A model for the induction of bladder cancer associated with schistosomiasis is proposed which takes into account the interrelationships between different factors resulting from the infection, especially the role of alkylating agents that can contribute to the induction of this neoplasm.
Description
Date
1992-04-30
Publisher
Collections
Keywords
Urinary Bladder Cancer
Type
Article
Citation
Involvement of alkylating agents in schistosome-associated bladder cancer: the possible basic mechanisms of induction. 1992, 63 (3):171-88 Cancer Lett.