A phase I and pharmacokinetic study of OSI-7904L, a liposomal thymidylate synthase inhibitor in combination with oxaliplatin in patients with advanced colorectal cancer.
Clamp, Andrew R Schöffski, Patrick Valle, Juan W Wilson, R Marreaud, Sandrine Govaerts, A-S Debois, M Lacombe, D Twelves, C Chick, J
Clamp, Andrew R
Schöffski, Patrick
Valle, Juan W
Wilson, R
Marreaud, Sandrine
Govaerts, A-S
Debois, M
Lacombe, D
Twelves, C
Chick, J
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Abstract
PURPOSE: OSI-7904L is a liposomal formulation of a potent thymidylate synthase (TS) inhibitor. This phase I study evaluated the safety, tolerability and pharmacokinetics (PK) of OSI-7904L administered in combination with oxaliplatin every 21 days in patients with advanced colorectal carcinoma. METHOD: A 3+3 study design was utilized at predefined dose levels. Polymorphisms in the TS enhancer region and XPD enzyme were investigated as potential predictors of efficacy and toxicity. RESULTS: Fourteen patients received 76 cycles of treatment. At the highest dose level (OSI-7904L 9 mg/m(2), oxaliplatin 130 mg/m(2)) investigated, one of nine patients experienced dose-limiting toxicity of grade 3 oral mucositis with cycle 1 and five further patients required dose reductions. The toxicity profile of stomatitis, diarrhea, nausea, fatigue, sensory neuropathy and skin rash was consistent with that expected for a TS inhibitor/oxaliplatin combination regimen. PK analysis showed high interpatient variability with no detectable interaction between OSI-7904L and oxaliplatin. Partial radiological responses were documented in two patients. CONCLUSIONS: The recommended regimen for further investigation is OSI-7904L 9 mg/m(2) and oxaliplatin 130 mg/m(2).
Description
Date
2008-04
Publisher
Keywords
Phase I
OSI-7904L
Oxaliplatin
Thymidylate Synthase
Colorectal Carcinoma
OSI-7904L
Oxaliplatin
Thymidylate Synthase
Colorectal Carcinoma
Type
Article
Citation
A phase I and pharmacokinetic study of OSI-7904L, a liposomal thymidylate synthase inhibitor in combination with oxaliplatin in patients with advanced colorectal cancer. 2008, 61 (4):579-85 Cancer Chemother. Pharmacol.