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A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans
Halova, Lenka Cobley, D. Franz-Wachtel, M. Wang, T. Morrison, K. R. Krug, K. Nalpas, N. Maček, B. Hagan, Iain M Humphrey, S. J.
Halova, Lenka
Cobley, D.
Franz-Wachtel, M.
Wang, T.
Morrison, K. R.
Krug, K.
Nalpas, N.
Maček, B.
Hagan, Iain M
Humphrey, S. J.
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Abstract
Fluctuations in TOR, AMPK and MAP-kinase signalling maintain cellular homeostasis and coordinate growth and division with environmental context. We have applied quantitative, SILAC mass spectrometry to map TOR and nutrient-controlled signalling in the fission yeast Schizosaccharomyces pombe. Phosphorylation levels at more than 1000 sites were altered following nitrogen stress or Torin1 inhibition of the TORC1 and TORC2 networks that comprise TOR signalling. One hundred and thirty of these sites were regulated by both perturbations, and the majority of these (119) new targets have not previously been linked to either nutritional or TOR control in either yeasts or humans. Elimination of AMPK inhibition of TORC1, by removal of AMPKα (ssp2
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2021
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Halova L, Cobley D, Franz-Wachtel M, Wang T, Morrison KR, Krug K, et al. A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans. Open Biol. 2021 Apr;11(4).