Autologous peripheral blood stem cell transplantation in first remission adult acute myeloid leukaemia--an intention to treat analysis and comparison of outcome using a predictive model based on the MRC AML10 cohort.
Ewing, Joanne Robertson, Jane D Kell, W Jonathan Burnett, Alan K Ryder, W David J Chang, James Morgenstern, Godfrey R Scarffe, J Howard Chopra, Rajesh
Ewing, Joanne
Robertson, Jane D
Kell, W Jonathan
Burnett, Alan K
Ryder, W David J
Chang, James
Morgenstern, Godfrey R
Scarffe, J Howard
Chopra, Rajesh
Citations
Altmetric:
Abstract
The role of autologous peripheral blood stem cell transplantation (APBSCT) in acute myeloid leukaemia (AML) remains controversial. The current study evaluated the application of APBSCT in a large consecutive series of patients with untreated AML, and compared outcome with a predictive model based on MRC AML10 data. Of 148 evaluable patients, 118 patients entered complete remission (CR) after induction therapy comprising three cycles of daunorubicin, cytosine arabinoside and oral 6-thioguanine. Of these patients, 68 (57%) proceeded to consolidation therapy with two courses of intermediate dose cytosine arabinoside, and stem cell mobilisation, and 40 of these patients (34%) underwent the APBSCT procedure after high dose busulphan conditioning. Harvest quality was the main factor precluding APBSCT. Five-year event-free survival (EFS) in patients who achieved CR was 38% and in APBSCT patients was 57%. There were no transplant-related deaths. No significant differences were demonstrated between observed and expected outcomes at 1 and 2 years, based on the predictive model derived from the MRC AML10 study. These data therefore indicate that only a third of eligible adult patients will undergo APBSCT. However, the results demonstrate favourable survival in such patients, with no transplant-related mortality.
Description
Date
2003-04
Publisher
Collections
Keywords
Myeloid Leukaemia
Haematopoietic Stem Cell Mobilisation
Haematopoietic Stem Cell Mobilisation
Type
Article
Citation
Autologous peripheral blood stem cell transplantation in first remission adult acute myeloid leukaemia--an intention to treat analysis and comparison of outcome using a predictive model based on the MRC AML10 cohort. 2003, 8 (2):83-90 Hematology