Treatment of advanced head and neck carcinoma with synchronous irradiation and methotrexate.
Pointon, R C S Askill, C Hunter, Robin D Wilkinson, Peter M
Pointon, R C S
Askill, C
Hunter, Robin D
Wilkinson, Peter M
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Abstract
Thirty-four patients with advanced head and neck cancer were treated by synchronous radiotherapy and methotrexate (MTX) (100 mg/m2). Complete resolution of disease was obtained in 18 patients, the median remission of patients being 17 months. In general, treatment was well tolerated, although mucosal reaction was prolonged in 50% of patients. Drug-induced hematological toxicity was observed in six patients (18%) and one patient died. As a result of these findings, a random clinical trial to compare X-ray therapy with X-ray therapy and MTX in advanced head and neck cancer has been commenced.
Description
Date
1981
Publisher
Collections
Keywords
Cancer Staging
Type
Article
Citation
Treatment of advanced head and neck carcinoma with synchronous irradiation and methotrexate. 1981, 65 Suppl 1:145-8 Cancer Treat Rep