The spindle pole body plays a key role in controlling mitotic commitment in the fission yeast Schizosaccharomyces pombe.
Hagan, Iain M
Hagan, Iain M
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Abstract
Commitment to mitosis is regulated by a conserved protein kinase complex called MPF (mitosis-promoting factor). MPF activation triggers a positive-feedback loop that further promotes the activity of its activating phosphatase Cdc25 and is assumed to down-regulate the MPF-inhibitory kinase Wee1. Four protein kinases contribute to this amplification loop: MPF itself, Polo kinase, MAPK (mitogen-activated protein kinase) and Greatwall kinase. The fission yeast SPB (spindle pole body) component Cut12 plays a critical role in modulating mitotic commitment. In this review, I discuss the relationship between Cut12 and the fission yeast Polo kinase Plo1 in mitotic control. These results indicate that commitment to mitosis is co-ordinated by control networks on the spindle pole. I then describe how the Cut12/Plo1 control network links growth control signalling from TOR (target of rapamycin) and MAPK networks to the activation of MPF to regulate the timing of cell division.
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Description
Date
2008-10
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Keywords
MAPK
Mitosis-Promoting Factor
MPF
Yeasts
Mitosis-Promoting Factor
MPF
Yeasts
Type
Article
Citation
The spindle pole body plays a key role in controlling mitotic commitment in the fission yeast Schizosaccharomyces pombe. 2008, 36 (Pt 5):1097-101 Biochem. Soc. Trans.