Promotion of prostatic metastatic migration towards human bone marrow stoma by Omega 6 and its inhibition by Omega 3 PUFAs.
Brown, Michael D Hart, Claire A Gazi, Ehsan Bagley, Steven
Brown, Michael D
Hart, Claire A
Gazi, Ehsan
Bagley, Steven
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Abstract
Epidemiological studies have shown not only a relationship between the intake of dietary lipids and an increased risk of developing metastatic prostate cancer, but also the type of lipid intake that influences the risk of metastatic prostate cancer. The Omega-6 poly-unsaturated fatty acid, Arachidonic acid, has been shown to enhance the proliferation of malignant prostate epithelial cells and increase the risk of advanced prostate cancer. However, its role in potentiating the migration of cancer cells is unknown. Here we show that arachidonic acid at concentrations
Description
Date
2006-03-27
Publisher
Keywords
Bone Marrow Cancer
Cancer Invasiveness
Prostatic Cancer
Tumour Cells
Cancer Invasiveness
Prostatic Cancer
Tumour Cells
Type
Article
Citation
Promotion of prostatic metastatic migration towards human bone marrow stoma by Omega 6 and its inhibition by Omega 3 PUFAs. 2006, 94 (6):842-53 Br. J. Cancer