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Plasma total cell-free DNA (cfDNA) is a surrogate biomarker for tumour burden and a prognostic biomarker for survival in metastatic melanoma patients.
Valpione, Sara Gremel, Gabriela Mundra, P A Middlehurst, P Galvani, Elena Girotti, Maria Romina Lee, Rebecca J Garner, G Dhomen, Nathalie Lorigan, Paul C
Valpione, Sara
Gremel, Gabriela
Mundra, P A
Middlehurst, P
Galvani, Elena
Girotti, Maria Romina
Lee, Rebecca J
Garner, G
Dhomen, Nathalie
Lorigan, Paul C
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Abstract
Tumour burden is a prognostic biomarker in metastatic melanoma. However, tumour burden is difficult to measure and there are currently no reliable surrogate biomarkers to easily and reliably determine it. The aim of this study was to assess the potential of plasma total cell free DNA as biomarker of tumour burden and prognosis in metastatic melanoma patients.
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2017-11-23
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Plasma total cell-free DNA (cfDNA) is a surrogate biomarker for tumour burden and a prognostic biomarker for survival in metastatic melanoma patients. 2017, 88:1-9 Eur J Cancer