Myofibroblast transformation in metastatic extramedullary chronic myeloid leukemia: a case report.
Ru, Yong-Xin Eyden, Brian P Li, Qing-Hua Mao, Bing-Yu Liu, En-Bin Pang, Tian-Xiang
Ru, Yong-Xin
Eyden, Brian P
Li, Qing-Hua
Mao, Bing-Yu
Liu, En-Bin
Pang, Tian-Xiang
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Abstract
Primary and metastatic carcinomas have a reactive stroma characterized by many myofibroblasts. These cells have also been documented in nonepithelial malignancies, such as sarcomas, malignant melanoma, and lymphoid tumors but in generally far fewer numbers. In non-Hodgkin's lymphoma, Hodgkin's disease, and leukemia, myofibroblasts are rather rarely documented. In particular, there appear to be no reports of myofibroblasts in either primary bone-marrow/peripheral blood leukemia or secondary deposits of leukemia. In this paper, a case of a relapsed chronic myeloid leukemia appearing in an inguinal lymph node is described, containing many myofibroblasts. The case is detailed and presented with a discussion on the role of myofibroblasts in the progression of nonepithelial cancers.
Description
Date
2009
Publisher
Collections
Keywords
Cancerous Cell Transformation
Myelogenic Leukaemia
Myelogenic Leukaemia
Type
Article
Citation
Myofibroblast transformation in metastatic extramedullary chronic myeloid leukemia: a case report. 2009, 33 (3):136-40 Ultrastruct Pathol