Allelic imbalance of chromosome 6q in ovarian tumours.
Orphanos, Vassilis McGown, Gail Hey, Yvonne Thorncroft, Mary R Santibanez-Koref, Mauro F Russell, S E Hickey, I Atkinson, R J Boyle, John M
Orphanos, Vassilis
McGown, Gail
Hey, Yvonne
Thorncroft, Mary R
Santibanez-Koref, Mauro F
Russell, S E
Hickey, I
Atkinson, R J
Boyle, John M
Citations
Altmetric:
Abstract
Previous work has implicated putative tumour-suppressor (ts) genes at 6q27 and a broad region at 6p12-q23. Here we report the results of a coded, randomised study of allelic imbalance at 12 loci on 6q on 40 pairs of coded tumour-blood pairs from patients with ovarian tumours. Our results provide clear evidence for the involvement of different regions of 6q in tumours of different histological subtypes. The involvement in serous tumours of a ts gene at the distal site is confirmed. However, proximal 6q presents a complex picture, with possibly three further ts genes: one at 6q21-23.3 involved at high frequency in benign and endometrioid tumours, another at 6q14-q15, also involved in endometrioid tumours, and a third suggested by a smallest region of deletion at 6q16.3-q21, between D6S275 and D6S300, that appears to be involved in early stage tumours. These observations point the way to a statistical study of the involvement of 6q in tumours of different histological type and staging performed on larger cohorts of samples.
Description
Date
1995-04
Publisher
Collections
Keywords
Cancer DNA
Cancer Staging
Endometrial Cancer
Ovarian Cancer
Cancer Staging
Endometrial Cancer
Ovarian Cancer
Type
Article
Citation
Allelic imbalance of chromosome 6q in ovarian tumours. 1995, 71 (4):666-9 Br. J. Cancer