Loading...
Heterogeneous distribution of DNA alkylation products in rat liver chromatin after in vivo administration of N,N-di[14C]methylnitrosamine.
Cooper, H K Margison, Geoffrey P O'Connor, Peter J Itzhaki, Ruth F
Cooper, H K
Margison, Geoffrey P
O'Connor, Peter J
Itzhaki, Ruth F
Citations
Altmetric:
Abstract
Poly-l-lysine (PL) binds to about 50% of chromatin DNA, rendering it resistant to degradation by DNAase I. Separation of the unbound DNA as acid-soluble nucleotides allows the fractionation of chromatin DNA into two zones. After in vivo administration of N,N-di[14C]methylnitrosamine, the amount of alkylation in DNA was found to be lower in the polylysine-binding regions. Some possible reasons for this heterogeneous distribution are discussed.
Description
Date
1975-12
Publisher
Collections
Keywords
Type
Article
Citation
Heterogeneous distribution of DNA alkylation products in rat liver chromatin after in vivo administration of N,N-di[14C]methylnitrosamine. 1975, 11 (6):483-92 Chem. Biol. Interact.