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Effect of TA-CIN (HPV 16 L2E6E7) booster immunisation in vulval intraepithelial neoplasia patients previously vaccinated with TA-HPV (vaccinia virus encoding HPV 16/18 E6E7).
Davidson, Emma J Faulkner, Rebecca L Sehr, Peter Pawlita, Michael Smyth, Lucy J C Burt, Deborah J Tomlinson, Anne E Hickling, Julian K Kitchener, Henry C Stern, Peter L
Davidson, Emma J
Faulkner, Rebecca L
Sehr, Peter
Pawlita, Michael
Smyth, Lucy J C
Burt, Deborah J
Tomlinson, Anne E
Hickling, Julian K
Kitchener, Henry C
Stern, Peter L
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Abstract
Heterologous prime-boost vaccination schedules employing TA-HPV, a vaccinia virus encoding HPV 16/18 E6 and E7, in combination with TA-CIN, an HPV 16 L2E6E7 fusion protein, may offer advantages over the use of either agent alone for the immunotherapy of human papillomavirus (HPV) type 16-associated vulval intraepithelial neoplasia (VIN). In the present study, 10 women with HPV 16-positive high grade VIN, previously primed with TA-HPV, received three booster immunisations with TA-CIN. All but one demonstrated HPV 16-specific proliferative T-cell and/or serological responses following vaccination. Three patients additionally showed lesion shrinkage or symptom relief, but no direct correlation between clinical and immunological responses was seen.
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Date
2004-07-29
Publisher
Collections
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Type
Article
Citation
Effect of TA-CIN (HPV 16 L2E6E7) booster immunisation in vulval intraepithelial neoplasia patients previously vaccinated with TA-HPV (vaccinia virus encoding HPV 16/18 E6E7). 2004, 22 (21-22):2722-9 Vaccine