Detailed mapping and loss of heterozygosity analysis suggests a suppressor locus involved in sporadic breast cancer within a distal region of chromosome band 17p13.3.
Stack, Maria Jones, David White, Gavin R M Liscia, D S Venesio, T Casey, G Crichton, D Varley, Jennifer Mitchell, Erika L D Heighway, Jim
Stack, Maria
Jones, David
White, Gavin R M
Liscia, D S
Venesio, T
Casey, G
Crichton, D
Varley, Jennifer
Mitchell, Erika L D
Heighway, Jim
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Abstract
The chromosome region 17p13.3 is thought to encode a tumour suppressor gene involved in sporadic breast cancer and other malignancies. Physical ordering of markers has been carried out by a series of multicolour fluorescent in situ hybridisation (FISH) experiments, using isolated yeast artificial chromosomes (YACs) and cosmids. Eight polymorphic markers ordered within this new physical map and one external marker were used to investigate the pattern of loss of heterozygosity in a panel of 40 sporadic breast tumour patients. The data revealed a region of high loss (60%) within distal 17p13.3, defined by markers D17S926, D17S695 and D17S849 which mapped close together. A contig of YACs was constructed physically linking these three markers.
Description
Date
1995-11
Publisher
Collections
Keywords
Breast Cancer
Tumour Suppressor Genes
Tumour Suppressor Genes
Type
Article
Citation
Detailed mapping and loss of heterozygosity analysis suggests a suppressor locus involved in sporadic breast cancer within a distal region of chromosome band 17p13.3. 1995, 4 (11):2047-55 Hum. Mol. Genet.