Acute lymphoblastic leukaemia following Hodgkin's disease is associated with a good prognosis.
Narayanan, M N Morgenstern, Godfrey R Chang, James Harrison, Christine J Ranson, Malcolm R Scarffe, J Howard
Narayanan, M N
Morgenstern, Godfrey R
Chang, James
Harrison, Christine J
Ranson, Malcolm R
Scarffe, J Howard
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Abstract
Acute leukaemia, both myeloid and lymphoblastic, in patients treated for Hodgkin's disease (HD) is thought to have a poor prognosis. We report four adults who developed secondary acute lymphoblastic leukaemia (ALL) following chemoradiotherapy for HD. The chromosomal translocation t(4;11) (q21;q23) was found in two patients who received a chemotherapeutic regimen containing the DNA topoisomerase II inhibitor etoposide. Three of the four patients are alive and in unmaintained first remission at 3, 5 and 9 years from diagnosis of ALL, two following autologous bone marrow transplantation. These results suggest that ALL following HD may have a good prognosis when treated aggressively.
Description
Date
1994-04
Publisher
Collections
Keywords
Second Primary Cancer
Precursor Cell Lymphoblastic Leukaemia-Lymphoma
Precursor Cell Lymphoblastic Leukaemia-Lymphoma
Type
Article
Citation
Acute lymphoblastic leukaemia following Hodgkin's disease is associated with a good prognosis. 1994, 86 (4):867-9 Br. J. Haematol.