Prospects for gene therapy using haemopoietic stem cells.
Fairbairn, Leslie J Ewing, Joanne
Fairbairn, Leslie J
Ewing, Joanne
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Abstract
Gene therapy has thus far promised much and delivered little. Much of this has been due to deficiencies in the reagents and methodologies employed in early clinical trials. Recent technological advances in vectors and haemopoietic stem cell manipulation, coupled with improved pre-clinical assays of gene transfer and expression in re-populating stem cells give cause for greater optimism. Here we review these advances and indicate areas requiring further development before clinical gene therapy in the haemopoietic system becomes a widely applicable treatment modality.
Authors
Description
Date
2001-12
Publisher
Collections
Keywords
Haematopoietic Stem Cells
Type
Article
Citation
Prospects for gene therapy using haemopoietic stem cells. 2001, 14 (4):823-34 Best Pract Res Clin Haematol