Evidence that an HLA-DQA1-DQB1 haplotype influences susceptibility to childhood common acute lymphoblastic leukaemia in boys provides further support for an infection-related aetiology.
Taylor, G Malcolm Dearden, Simon Payne, N Ayres, Michelle Gokhale, D A Birch, Jillian M Blair, Val Stevens, Richard F Will, Andrew M Eden, Tim O B
Taylor, G Malcolm
Dearden, Simon
Payne, N
Ayres, Michelle
Gokhale, D A
Birch, Jillian M
Blair, Val
Stevens, Richard F
Will, Andrew M
Eden, Tim O B
Citations
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Abstract
Comparison of DQA1 and DQB1 alleles in 60 children with common acute lymphoblastic leukaemia (c-ALL) and 78 newborn infant control subjects revealed that male but not female patients had a higher frequency of DQA1*0101/*0104 and DQB1*0501 than appropriate control subjects. The results suggest a male-associated susceptibility haplotype in c-ALL and supports an infectious aetiology.
Description
Date
1998-09
Publisher
Collections
Keywords
Precursor Cell Lymphoblastic Leukaemia-Lymphoma
Type
Article
Citation
Evidence that an HLA-DQA1-DQB1 haplotype influences susceptibility to childhood common acute lymphoblastic leukaemia in boys provides further support for an infection-related aetiology. 1998, 78 (5):561-5 Br. J. Cancer