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Fragment-based hit identification: thinking in 3D.
Morley, A Pugliese, A Birchall, K Bower, J Brennan, P Brown, N Chapman, T Drysdale, M Gilbert, I Hoelder, S
Morley, A
Pugliese, A
Birchall, K
Bower, J
Brennan, P
Brown, N
Chapman, T
Drysdale, M
Gilbert, I
Hoelder, S
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Abstract
The identification of high-quality hits during the early phases of drug discovery is essential if projects are to have a realistic chance of progressing into clinical development and delivering marketed drugs. As the pharmaceutical industry goes through unprecedented change, there are increasing opportunities to collaborate via pre-competitive networks to marshal multifunctional resources and knowledge to drive impactful, innovative science. The 3D Fragment Consortium is developing fragment-screening libraries with enhanced 3D characteristics and evaluating their effect on the quality of fragment-based hit identification (FBHI) projects.
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2013-12
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Article
Citation
Fragment-based hit identification: thinking in 3D. 2013, 18 (23-24):1221-7 Drug Discov Today