The intrinsic radiosensitivity of normal and tumour cells.
West, Catharine M L Davidson, Susan E Elyan, S A Swindell, Ric Roberts, Stephen A Orton, C J Coyle, C A Valentine, Helen R Wilks, Deepti P Hunter, Robin D
West, Catharine M L
Davidson, Susan E
Elyan, S A
Swindell, Ric
Roberts, Stephen A
Orton, C J
Coyle, C A
Valentine, Helen R
Wilks, Deepti P
Hunter, Robin D
Citations
Altmetric:
Abstract
PURPOSE: To examine whether in vitro measurements of normal and tumour cell radiosensitivity can be used as prognostic factors in clinical oncology. MATERIALS AND METHODS: Stage I-III cervix carcinoma patients were treated with radical radiotherapy with a minimum of 3 years' follow-up. Lymphocyte and tumour radiosensitivities were assayed using, respectively, a limiting dilution and soft agar clonogenic assay to obtain surviving fraction at 2 Gy (SF2). The results were related, in an actuarial analysis, to late morbidity assessed using the Franco Italian glossary. RESULTS: Patients with radiosensitive lymphocytes had a significantly increased risk of developing late complications (n = 93, p = 0.002). Increasing tumour radiosensitivity was associated with an increased risk of morbidity (n= 113, p=0.032). A significant correlation was found between fibroblast and tumour cell radiosensitivity (r=0.57, p=0.03), but a weak inverse association was found between lymphocyte and tumour cell radiosensitivity (r= -0.32, p=0.03). Patients with radiosensitive lymphocytes and tumour cells had higher levels of late complications than those whose cells were radioresistant. CONCLUSION: The work described highlights the importance of cellular radiosensitivity as a parameter determining the clinical response to radiotherapy.
Description
Date
1998-04
Publisher
Keywords
Cancer Staging
Uterine Cervical Cancer
Uterine Cervical Cancer
Type
Article
Citation
The intrinsic radiosensitivity of normal and tumour cells. 1998, 73 (4):409-13 Int. J. Radiat. Biol.