Loading...
Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer.
Hessmann, E Patzak, M S Klein, L Chen, N Kari, V Ramu, I Bapiro, T E Frese, Kristopher K Gopinathan, A Richards, F M
Hessmann, E
Patzak, M S
Klein, L
Chen, N
Kari, V
Ramu, I
Bapiro, T E
Frese, Kristopher K
Gopinathan, A
Richards, F M
Citations
Altmetric:
Abstract
Desmoplasia and hypovascularity are thought to impede drug delivery in pancreatic ductal adenocarcinoma (PDAC). However, stromal depletion approaches have failed to show clinical responses in patients. Here, we aimed to revisit the role of the tumour microenvironment as a physical barrier for gemcitabine delivery.
Description
Date
2017-01-10
Publisher
Collections
Files
Keywords
Type
Article
Citation
Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer. 2017, Gut