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Composite nanoarchitectonics of photoactivated titania-based materials with anticancer properties
Papadopoulou-Fermeli, N. Lagopati, N. Pippa, N. Sakellis, E. Boukos, N. Gorgoulis, Vassilis G Gazouli, M. Pavlatou, E. A.
Papadopoulou-Fermeli, N.
Lagopati, N.
Pippa, N.
Sakellis, E.
Boukos, N.
Gorgoulis, Vassilis G
Gazouli, M.
Pavlatou, E. A.
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Abstract
The synthesis of titania-based composite materials with anticancer potential under visible-light irradiation is the aim of this study. In specific, titanium dioxide (TiO2) nanoparticles (NPs) chemically modified with silver were embedded in a stimuli-responsive microgel (a crosslinked interpenetrating network (IP) network that was synthesized by poly (N-Isopropylacrylamide) and linear chains of polyacrylic acid sodium salt, forming composite particles. The ultimate goal of this research, and for our future plans, is to develop a drug-delivery system that uses optical fibers that could efficiently photoactivate NPs, targeting cancer cells. The produced Ag-TiO2 NPs, the microgel and the composite materials were characterized through X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), micro-Raman spectroscopy, ultraviolet-visible spectroscopy (UV-Vis), dynamic light scattering (DLS) and transmission electron microscopy (TEM). Our results indicated that Ag-TiO2 NPs were successfully embedded within the thermoresponsive microgel. Either Ag-TiO2 NPs or the composite materials exhibited high photocatalytic degradation efficiency on the pollutant rhodamine B and significant anticancer potential under visible-light irradiation.
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Date
2022
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Papadopoulou-Fermeli N, Lagopati N, Pippa N, Sakellis E, Boukos N, Gorgoulis VG, et al. Composite Nanoarchitectonics of Photoactivated Titania-Based Materials with Anticancer Properties. Pharmaceutics. 2022 Dec 30;15(1). PubMed PMID: 36678763. Pubmed Central PMCID: PMC9864881. Epub 2023/01/22. eng.