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IRIS study: a phase II study of the steroid sulfatase inhibitor Irosustat when added to an aromatase inhibitor in ER-positive breast cancer patients.
Palmieri, C Stein, R Liu, X Hudson, E Nicholas, H Sasano, H Guestini, F Holcombe, C Barrett, S Kenny, L
Palmieri, C
Stein, R
Liu, X
Hudson, E
Nicholas, H
Sasano, H
Guestini, F
Holcombe, C
Barrett, S
Kenny, L
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Abstract
Irosustat is a first-generation, orally active, irreversible steroid sulfatase inhibitor. We performed a multicentre, open label phase II trial of the addition of Irosustat to a first-line aromatase inhibitor (AI) in patients with advanced BC to evaluate the safety of the combination and to test the hypothesis that the addition of Irosustat to AI may further suppress estradiol levels and result in clinical benefit.
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2017-06-13
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IRIS study: a phase II study of the steroid sulfatase inhibitor Irosustat when added to an aromatase inhibitor in ER-positive breast cancer patients. 2017 Breast Cancer Res Treat