Patient-reported functional outcomes after hypofractionated radiation for prostate cancer
NossiteR, J. Sujenthiran, A. Cowling, T. Parry, M. Charman, S. Cathcart, P. Clarke, Noel W Payne, H. Van der Meulen, J Aggarwal, A.
NossiteR, J.
Sujenthiran, A.
Cowling, T.
Parry, M.
Charman, S.
Cathcart, P.
Clarke, Noel W
Payne, H.
Van der Meulen, J
Aggarwal, A.
Citations
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Abstract
Purpose or Objective
To determine patient-reported functional outcomes
(PROs) in men with prostate cancer (PCa) undergoing
moderately hypofractionated (H-RT) or conventionally
fractionated radiotherapy (C-RT) in a national cohort
study.
Material and Methods
All men diagnosed with PCa between April 2014 and
September 2016 in the English National Health Service
undergoing C-RT or H-RT were identified in the National
Prostate Cancer Audit and mailed a questionnaire at least
18 months after diagnosis. Differences in patient-reported
urinary, bowel, sexual, and hormonal function (EPIC-26
domain scores on a 0-100 scale) and health-related quality
of life (EQ5D5L on a 0-1 scale) were estimated using linear
regression with adjustment for patient, tumour and
treatment-related factors in addition to gastrointestinal
(GI) and genitourinary (GU) baseline function with higher
scores representing better outcomes.
Results
Of the 17,058 men in the cohort, 77% responded: 8,432
men had C-RT (64.2%) and 4,699 H-RT (35.8%). Men in the
H-RT group were older (≥70 years: 67.5% versus 60.9%),
fewer men had locally advanced disease (56.5% versus
71.3%), were less likely to receive ADT (79.5% versus
87.8%) and slightly more men had pre-treatment GU procedures (24.2% versus 21.2%). H-RT was associated with
small increases in adjusted mean EPIC-26 sexual (3.3
points; 95% CI 2.1-4.5, p<0.001) and hormonal function
scores (3.2 points; CI 1.8-4.6, p<0.001). These differences
failed to meet established thresholds for a clinically
meaningful change. There were no statistically significant
differences in urinary or bowel function and quality of life.
Conclusion
This is the first national cohort study comparing functional
outcomes after H-RT and C-RT reported by patients. These
‘real-world’ results further support the use of H-RT as the
standard for radiotherapy in men with non-metastatic PCa.
Description
Date
2020
Publisher
Collections
Keywords
Type
Meetings and Proceedings
Citation
NossiteR J, Sujenthiran A, Cowling T, Parry M, Charman S, Cathcart P, et al. OC-0212: Patient-reported functional outcomes after hypofractionated radiation for prostate cancer. Radiotherapy and Oncology . 2020 Nov;152:S106–7.