Loading...
A multivariate analysis of factors affecting survival in patients with high-grade histology non-Hodgkin's lymphoma.
Steward, William P Todd, Ian D Harris, Martin Jones, J M Blackledge, G Wagstaff, John Anderson, Heather Wilkinson, Peter M Crowther, Derek
Steward, William P
Todd, Ian D
Harris, Martin
Jones, J M
Blackledge, G
Wagstaff, John
Anderson, Heather
Wilkinson, Peter M
Crowther, Derek
Citations
Altmetric:
Abstract
One hundred and eleven patients with advanced-stage, high-grade histology non-Hodgkin's lymphoma were studied over a 7-yr period and were treated with one form of chemotherapy and radiotherapy. Multivariate analyses were carried out to identify factors which could predict a favourable prognosis. A complete response, low serum LDH and absence of clinical evidence of liver involvement were associated with long-term survival. The presence of 'B' symptoms, bone marrow involvement, low serum albumin and male sex predicted a reduced chance of achieving a complete remission. For those patients who achieved a complete response, the subdivision of histologies, particularly according to the Kiel classification, was the only significant factor predictive of prolonged relapse-free and overall survival. This confirms the importance of identifying different histological subgroups of lymphoma when considering treatment planning.
Description
Date
1984-07
Publisher
Collections
Keywords
Cancer Staging
Type
Article
Citation
A multivariate analysis of factors affecting survival in patients with high-grade histology non-Hodgkin's lymphoma. 1984, 20 (7):881-9 Eur J Cancer Clin Oncol