Comprehensive validation of cardiovascular magnetic resonance techniques for the assessment of myocardial extracellular volume.
Miller, C Naish, J Bishop, P Coutts, Glyn Clark, D Zhao, S Ray, S Yonan, N Williams, S Flett, A
Miller, C
Naish, J
Bishop, P
Coutts, Glyn
Clark, D
Zhao, S
Ray, S
Yonan, N
Williams, S
Flett, A
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Abstract
Extracellular matrix expansion is a key element of ventricular remodeling and a potential therapeutic target. Cardiovascular magnetic resonance (CMR) T1-mapping techniques are increasingly used to evaluate myocardial extracellular volume (ECV); however, the most widely applied methods are without histological validation. Our aim was to perform comprehensive validation of (1) dynamic-equilibrium CMR (DynEq-CMR), where ECV is quantified using hematocrit-adjusted myocardial and blood T1 values measured before and after gadolinium bolus; and (2) isolated measurement of myocardial T1, used as an ECV surrogate.
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2013-05-01
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Comprehensive validation of cardiovascular magnetic resonance techniques for the assessment of myocardial extracellular volume. 2013, 6 (3):373-83 Circ Cardiovasc Imaging