A latent reactive handle for functionalising heparin-like and LMWH deca- and dodecasaccharides.
Miller, G Broberg, K Rudd, C Helliwell, M Jayson, Gordon C Gardiner, J
Miller, G
Broberg, K
Rudd, C
Helliwell, M
Jayson, Gordon C
Gardiner, J
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Abstract
d-Glucosamine derivatives bearing latent O4 functionality provide modified H/HS-type disaccharide donors for a final stage capping approach enabling introduction of conjugation-suitable, non-reducing terminal functionality to biologically important glycosaminoglycan oligosaccharides. Application to the synthesis of the first O4-terminus modified synthetic LMWH decasaccharide and an HS-like dodecasaccharide is reported.
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2015-12-14
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A latent reactive handle for functionalising heparin-like and LMWH deca- and dodecasaccharides. 2015, 13 (46):11208-19 Org Biomol Chem