Residual Ph- cells in chronic myeloid leukemia: detection and usefulness.
Chang, James Coutinho, Lucia H Santos, A M Brereton, M L Harrison, Christine J Testa, Nydia G
Chang, James
Coutinho, Lucia H
Santos, A M
Brereton, M L
Harrison, Christine J
Testa, Nydia G
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Abstract
Bone marrow cells from patients with chronic myeloid leukemia (CML) in in vitro long-term bone marrow culture (LTBMC) show an impaired survival of Philadelphia (Ph) positive cells and, in a proportion of patients, the emergence of Philadelphia negative hemopoiesis. The standard conditions of in vitro cultures provide optimal purging effect. Selected patients can now have autologous bone marrow transplants (ABMT) with in vitro purged cells.
Description
Date
1993-05
Publisher
Keywords
Cultured Tumour Cells
Leukaemia
Leukaemia
Type
Article
Citation
Residual Ph- cells in chronic myeloid leukemia: detection and usefulness. 1993, 11 Suppl 1:59-61 Stem Cells